Methodological Advances in Evaluating Abuse Deterrent Opioid Analgesics

We will work on text analysis to determine the role various drugs/medications played for individual’s death. We will try to run a set of programs developed by the National Center for Health Statistics (NCHS) and shared on GitHub National-Vital-Statistics-Mortality-Data/README.md at master · CDCgov/National-Vital-Statistics-Mortality-Data · GitHub. The programs allow for parallel processing threads for record selection for large data files. We will analyze the literal text on Kentucky death certificates for decedents who died from drug overdose, 2018-2021. Out team has access to the data due to a data use agreement with the state office of vital statsitics.

Personnel:

Principal investigator- Svetla Slavova, Associate Professor, Department of Biostatistics, Added 08/04/2021

Data analyst- Candace Brancato, Director of Biomedical Data Science, Opioid/Subst Abuse RPA

Computational consulting- Taylor D. Smith, Data Management Specialist Sr, Institute for Biomedical Informatics

Computational Methods:

Text analysis programs developed by the NCHS (https://github.com/CDCgov/National-Vital-Statistics-Mortality-Data/tree/master/Drug-and-Substance/Drug-Mentions-With-Involvement ) and applied to Kentucky data set. We will also develop and evaluate new methods.

Software:

Microsoft Windows 10 operating system, Microsoft Excel, and SAS Foundation or Base SAS.

UK and non-UK Collaborators:

UK Data analyst- Candace Brancato, Director of Biomedical Data Science, Opioid/Subst Abuse RPA

UK Computational consulting- Taylor D. Smith, Data Management Specialist Sr, Institute for Biomedical Informatics

Grants:

Food and Drug Administration (grant HHSF223201810183C) under Broad Agency Announcement No. 17-00123, and approved by the UK IRB

Publications:

Svetla Slavova, PhD1,2; Dana Quesinberry, DrPH1,3; Sarah Hargrove, MS1; et al Peter Rock, MPH4; Candace Brancato, MS2; Patricia R. Freeman, PhD5; Sharon L. Walsh, PhD6,7. Trends in Drug Overdose Mortality Rates in Kentucky, 2019-2020 JAMA Netw Open. 2021;4(7):e2116391. doi:10.1001/jamanetworkopen.2021.16391

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