BMI_633_F21
BMI 633 Introduction to Bioinformatics
Course Syllabus Fall 2021
Lecturers: Drs. Jin Chen and Jong Cheol Jeong
Guest lectures: Drs. Cody Bumgardner, Qiang Cheng, Jinpeng Liu, Kangmei Zhao (Stanford), Chi Wang, and Eric Durbin
Date: Aug 23 – Dec 8 2021
Time: M/W 1-2:30 PM
Location: MDS 211
Date | Title | Lecturer(s) | Memo |
Aug 23 | What is bioinformatics? | Jin Chen | Introduction class; all welcome |
Aug 25 | Essentials of molecular biology; R programming part 1 (tutorial) | Jong Cheol Jeong Jin Chen | |
Aug 30 | Essentials of sequencing technology; R programming part 2 (tutorial) | Jong Cheol Jeong Jin Chen | |
Sep 1 | Sequence alignment part 1: string matching, global alignment | Jin Chen | |
Sep 6 | NO CLASS | Labor Day | |
Sep 8 | Sequence alignment part 2: local alignment; BLASTÂ (tutorial) | Jin Chen | Supercomputer account setup |
Sep 13 | DNA-seq analysis pipeline; Galaxy part 1 (tutorial) | Jong Cheol Jeong | |
Sep 15Â | Production NGS for clinical diagnostics | Cody Bumgardner (confirmed) | Guest lecture; Coursework 1 announcement |
Sep 20 | Burrows-Wheeler transform;Â R programming part 3 (tutorial) | Jin Chen | |
Sep 22 | Genomics applications; R programming part 4 (tutorial) | Jin Chen | Coursework 1 due |
Sep 27 | Genome-wide association study; PLINK lab-type application (tutorial)Â | Jin Chen | |
Sep 29 | Genomics applications; R programming part 5 (tutorial) | Jin Chen | |
Oct 4 | RNAseq analysis pipeline; Galaxy part 2 (tutorial) | Jin Chen | |
Oct 6 | Differential expression analysis 1: RSEMÂ | Jin Chen | Coursework 2 announcement |
Oct 11 | Differential expression analysis 2: Deseq2 | Jin Chen | |
Oct 13 | Differential expression analysis 3: Beyond differential expression | Jin Chen | Term project announcement; Coursework 2 due |
Oct 18 | Gene set enrichment analysis; GSEA tutorial | Jong Cheol Jeong | |
Oct 20 | Mid-term exam | Jin Chen | Close-book exam |
Oct 25 | NO CLASS | Fall break | |
| Cancer radiogenomics | Qiang Cheng | Guest lecture |
Nov 1 | Differential expression analysis 4: non-coding RNA; miRDeep (tutorial) | Jin Chen | |
Nov 3 | Single-cell RNAseq 1: cell type detection; Seurat (tutorial) | Jin Chen | Coursework 3 announcement |
Nov 8 | Gut metagenomics | Jinpeng Liu (confirmed) | Guest lecture |
Nov 10 | Single-cell RNAseq 2: cell trajectory; Monocle (tutorial) | Jin Chen | Coursework 3 due |
Nov 15 | Single-cell RNAseq 3: reduce dimension and cell alignment | Jin Chen | |
Nov 17 | Systems biology & Epigenetics | Jin Chen | |
Nov 23 | Phenomics & exposome | Jin Chen | |
Nov 25 | NO CLASS | Thanksgiving | |
Nov 30 | Biological networks | Kangmei Zhao@Stanford (confirmed) | Guest online lecture; Coursework 4 announcement |
Dec 1 | Cancer Genomics | Chi Wang (confirmed) | Guest lecture; Coursework 4 due |
Dec 6 | Cancer genomics infrastructure | Eric Durbin (confirmed) | Â Guest lecture |
Dec 8 | Final project presentation | Write-up, presentation |
Optional topics:
- Translational bioinformatics and precision medicine (Haiquan Li)
- Network biology (Jin Chen)
- Metagenomics: population change over time & pathway-level variation (Jinpeng Liu)
- Metagenomics, DIAMOND
Center for Computational Sciences