Group research activities:

Translational research focused on heart failure including computer modeling that deploys multiscale approaches that span from millisecond-duration molecular function to month-long organ-level growth
https://www.campbellmusclelab.org

Project:

Data-driven optimization of therapy for heart failure: NIH HL163977
Summary: Deploy computer modeling at cell to organ-level scales to predict optimal therapies for patients who have different forms of heart failure with reduced ejection fraction.
Personnel: Kenneth Campbell (Faculty), Utku Gulbulak (Postdoc)

Computational methods:

We use multiscale finite element (FE) modeling techniques in the FEniCS framework, which is an open-source FE solver.  This includes a modular structure that couples ODE systems, which represent calcium and binding kinetics, to the PDE system that represents global structural mechanics.

Software:

FEniCS, SingularityP

Collaborators:

UK, Ken Campbell, PhD, Utku Gulbulak, PhD