Deng, Pan

Deng Lab Introduction:

Environmental pollutants have become an increasingly common health hazard in the last several decades. Recently, a number of studies have demonstrated the profound relationship between gut microbiota and our health. Gut microbiota are very sensitive to environmental pollutants and diets. In our previous study, we demonstrated that exposure to organic persistent pollutants led to disturbance of gut microbial and host metabolism. In this project, we aimed to investigate the interactions between gut microbiome and host in responses to environmental pollutant exposure and nutritional interventions. Mice fed with different diets were exposed to environmental pollutant(s), and cecum contents were collected and analyzed by using shotgun metagenomics.

Personnel:

Pan Deng (PI)

Jerika Durham (Graduate RA)

Computational Methods:

MetaPhlAn (Metagenomic Phylogenetic Analysis), Bowtie2, PICRUSt (Phylotypic Investigation of Communities by Reconstruction of Unobserved States) will be used.

Software:  

Fasnicar, HUMAnN, PICRUSt, Bowtie2, MetaPhlAn

Collaborators:

Dr. Chi Wang and Dr. Jinpeng Liu

(Markey Cancer Center, College of Medicine, University of Kentucky)

Grants:

Publications: